Cytokinesis: GAGs Form the Walls that Separate Our Parts
نویسندگان
چکیده
Cytokinesis, the final step of cell division, involves the formation of membranous barriers that partition cytosol and organelles between the resultant daughter cells. Recent studies reveal a crucial role for the extracellular glycosaminoglycan chondroitin in the completion of the cleavage furrow in dividing Caenorhabditis elegans embryos.
منابع مشابه
Survival and cytokinesis of Saccharomyces cerevisiae in the absence of chitin.
Most fungal cell walls are constructed with significant amounts of chitin, a linear polysaccharide that contributes mechanical resistance to the structure. In the yeast Saccharomyces cerevisiae, chitin is synthesized by three different isozymes, each of which has a separate cellular function. In this yeast, the most important role of chitin is in cytokinesis, when a thin primary septum is synth...
متن کاملA Genetic Screen for Mutations Affecting Cell Division in the Arabidopsis thaliana Embryo Identifies Seven Loci Required for Cytokinesis
Cytokinesis in plants involves the formation of unique cellular structures such as the phragmoplast and the cell plate, both of which are required to divide the cell after nuclear division. In order to isolate genes that are involved in de novo cell wall formation, we performed a large-scale, microscope-based screen for Arabidopsis mutants that severely impair cytokinesis in the embryo. We reco...
متن کاملAssembly of ring canals in the male germ line from structural components of the contractile ring.
Stable intercellular bridges called ring canals form following incomplete cytokinesis, and interconnect mitotically or meiotically related germ cells. We show that ring canals in Drosophila melanogaster males are surprisingly different from those previously described in females. Mature ring canal walls in males lack actin and appear to derive directly from structural proteins associated with th...
متن کاملPlant Cytokinesis: Motoring To The Finish
Cytokinesis in plant cells involves a microtubule-containing structure, the phragmoplast, which guides the formation of new cell walls. Recent studies have identified kinesin-like proteins that appear to play a variety of roles in plant cytokinesis.
متن کاملBench-to-bedside review: The role of glycosaminoglycans in respiratory disease
The extracellular matrix (ECM) plays a significant role in the mechanical behaviour of the lung parenchyma. The ECM is composed of a three-dimensional fibre mesh that is filled with various macromolecules, among which are the glycosaminoglycans (GAGs). GAGs are long, linear and highly charged heterogeneous polysaccharides that are composed of a variable number of repeating disaccharide units. T...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Current Biology
دوره 13 شماره
صفحات -
تاریخ انتشار 2003